FGFR1 CLIA Kit for Human(Homo sapiens) | EIAab.comFGFR1 CLIA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > FGFR1(Gene name) > Human

FGFR1 (Gene name),

Fibroblast growth factor receptor 1 (Protein name ), FGFR1_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

FGFR1(BFGFR;CEK;FGFBR;FLG;FLT2;HBGFR);

Protein name:

Fibroblast growth factor receptor 1(FGFR-1);

Alternative:

Fms-like tyrosine kinase 2(FLT-2);Basic fibroblast growth factor receptor 1(BFGFR;bFGF-R-1);Proto-oncogene c-Fgr;N-sam;

CD:

CD331;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. Homodimer after ligand binding. Interacts predominantly with FGF1 and FGF2, but can also interact with FGF3, FGF4, FGF5, FGF6, FGF8, FGF10, FGF19, FGF21, FGF22 and FGF23 (in vitro). Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Likewise, KLB increases the affinity for FGF19, FGF21 and FGF23. Interacts (phosphorylated on Tyr-766) with PLCG1 (via SH2 domains). Interacts with FRS2A. Interacts (via C-terminus) with NEDD4 (via WW3 domain). Interacts with KL (By similarity). Interacts with SHB (via SH2 domain) and GRB10. Interacts with KAL1; this interaction does not interfere with FGF2-binding to FGFR1, but prevents binding of heparin-bound FGF2. Interacts with SOX2 and SOX3.

Function:

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2A, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2A triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Nucleus Cytoplasm cytosol Cytoplasmic vesicle After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.

Protein Attributes:

Sequence length:

822

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

822:

LPEEPCLPRH | PAQLANGGLK | RR

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

String:

P11362

UniGene:

Hs.264887

Pfam:

PF07679

KEGG:

hsa:2260

SMR:

P11362

MIM:

101600

Uniprot:

P11362

FOR

ELISA Kit for Human FGFR-1

Cat.:

E0074m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human FGFR-1

Cat.:

E0074h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human FGFR-1

Cat.:

E0074r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human FGFR-1

Cat.:

E0074c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human FGFR-1

Cat.:

U0074h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human FGFR-1

Cat.:

U0074r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human FGFR-1

Cat.:

U0074c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human FGFR-1

Cat.:

U0074m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human FGFR-1

Cat.:

P0074Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human FGFR-1

Cat.:

P0074Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human FGFR-1

Cat.:

P0074Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human FGFR-1

Protein for Human FGFR-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA."
Itoh N. , Terachi T. , Ohta M. , Seo M.K.
Biochem. Biophys. Res. Commun.169:680-685(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 15)
tissue: Placenta.
2.

"Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors."
Dionne C.A. , Crumley G.R. , Bellot F. , Kaplow J.M. , Searfoss G. , Ruta M. , Burgess W.H. , Jaye M. , Schlessinger J.
EMBO J.9:2685-2692(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH FGF1 AND FGF2
tissue: Neonatal brain stem.
3.

"Diverse forms of a receptor for acidic and basic fibroblast growth factors."
Johnson D.E. , Lee P.L. , Lu J. , Williams L.T.
Mol. Cell. Biol.10:4728-4736(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6; 15; 17 AND 18)
4.

"Complete sequence of a human receptor for acidic and basic fibroblast growth factors."
Isacchi A. , Bergonzoni L. , Sarmientos P.
Nucleic Acids Res.18:1906-1906(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Placenta.
5.

"cDNA cloning and expression of a human FGF receptor which binds acidic and basic FGF."
Wennstroem S. , Sandstroem C. , Claesson-Welsh L.
Growth Factors4:197-208(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 14);INTERACTION WITH FGF1 AND FGF2
tissue: Teratocarcinoma.
6.

"Molecular cloning of a human basic fibroblast growth factor receptor cDNA and expression of a biologically active extracellular domain in a baculovirus system."
Kiefer M.C. , Baird A. , George-Nascimento C. , Nguyen T. , Mason O.B. , Boley L.J. , Valenzuela P. , Barr P.J.
Growth Factors5:115-127(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 14)
7.

"Alternative splicing generates at least five different isoforms of the human basic-FGF receptor."
Eisemann A. , Ahn J.A. , Graziani G. , Tronick S.R. , Ron D.
Oncogene6:1195-1202(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 6; 14; 15 AND 16)
tissue: Lung.
8.

"Fibroblast growth factor receptors from liver vary in three structural domains."
Hou J. , Kan M. , McKeehan K. , McBride G. , Adams P. , McKeehan W.L.
Science251:665-668(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12 AND 13)
tissue: Liver.
9.

"K-sam-related gene, N-sam, encodes fibroblast growth factor receptor and is expressed in T-lymphocytic tumors."
Hattori Y. , Odagiri H. , Katoh O. , Sakamoto H. , Morita T. , Shimotohno K. , Tobinai K. , Sugimura T. , Terada M.
Cancer Res.52:3367-3371(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
10.

"A case of Kallmann syndrome carrying a missense mutation in alternatively spliced exon 8A encoding the immunoglobulin-like domain IIIb of fibroblast growth factor receptor 1."
Miura K. , Miura S. , Yoshiura K. , Seminara S. , Hamaguchi D. , Niikawa N. , Masuzaki H.
Hum. Reprod.25:1076-1080(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 19);ROLE IN DISEASE
11.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6; 14 AND 21)
tissue: Placenta.
tissue: Testis.
12.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 14 AND 20)
tissue: Brain.
tissue: Colon.
13.

NIEHS SNPs program
Submitted (2004-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-22; ARG-818 AND CYS-822
14.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
15.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 14 AND 15);VARIANT GLY-213
tissue: Pancreas.
tissue: Testis.
tissue: Uterus.
16.

"Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization."
Pantoliano M.W. , Horlick R.A. , Springer B.A. , Van Dyk D.E. , Tobery T. , Wetmore D.R. , Lear J.D. , Nahapetian A.T. , Bradley J.D. , Sisk W.P.
Biochemistry33:10229-10248(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-370 (ISOFORM 15);PROTEIN SEQUENCE OF 22-129 (ISOFORM 15)
17.

"Distinct role of 2-O-, N-, and 6-O-sulfate groups of heparin in the formation of the ternary complex with basic fibroblast growth factor and soluble FGF receptor-1."
Rusnati M. , Coltrini D. , Caccia P. , Dell'Era P. , Zoppetti G. , Oreste P. , Valsasina B. , Presta M.
Biochem. Biophys. Res. Commun.203:450-458(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 81-100 (ISOFORMS 1/2/4/5/14/16)
18.

"A novel protein tyrosine kinase gene whose expression is modulated during endothelial cell differentiation."
Ruta M. , Howk R. , Ricca G. , Drohan W. , Zabelshansky M. , Laureys G. , Barton D.E. , Francke U. , Schlessinger J. , Givol D.
Oncogene3:9-15(1988)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 201-822 (ISOFORMS 1/6/10/14/15)
19.

"The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain."
Johnson D.E. , Lu J. , Chen H. , Werner S. , Williams L.T.
Mol. Cell. Biol.11:4627-4634(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 313-391 (ISOFORMS 17/18);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 313-360 (ISOFORMS 1/2/4/5/6/7/8/9/10/11/12/13/14/15);NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 313-360 (ISOFORM 19);TISSUE SPECIFICITY
tissue: Foreskin fibroblast.
tissue: Umbilical vein.
20.

"A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes."
Gutkind S.J. , Link D.C. , Katamine S. , Lacal P. , Miki T. , Ley T.J. , Robbins K.C.
Mol. Cell. Biol.11:1500-1507(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA]
21.

"A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1."
Mohammadi M. , Honegger A.M. , Rotin D. , Fischer R. , Bellot F. , Li W. , Dionne C.A. , Jaye M. , Rubinstein M. , Schlessinger J.
Mol. Cell. Biol.11:5068-5078(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLCG1
22.

"Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis."
Peters K.G. , Marie J. , Wilson E. , Ives H.E. , Escobedo J. , del Rosario M. , Mirda D. , Williams L.T.
Nature358:678-681(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-766;FUNCTION;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;INTERACTION WITH PLCG1
23.

"Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis."
Mohammadi M. , Dionne C.A. , Li W. , Lin N. , Spivak T. , Honegger A.M. , Jaye M. , Schlessinger J.
Nature358:681-684(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-766;FUNCTION IN CELL PROLIFERATION
24.

"Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766."
Sorokin A. , Mohammadi M. , Huang J. , Schlessinger J.
J. Biol. Chem.269:17056-17061(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-766;SUBCELLULAR LOCATION
25.

"Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction."
Mohammadi M. , Dikic I. , Sorokin A. , Burgess W.H. , Jaye M. , Schlessinger J.
Mol. Cell. Biol.16:977-989(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-463; TYR-583; TYR-585; TYR-653; TYR-654 AND TYR-730;CATALYTIC ACTIVITY;ENZYME REGULATION;FUNCTION IN PHOSPHORYLATION OF PLCG1 AND SHC1; ACTIVATION OF MAP KINASES AND REGULATION OF CELL PROLIFERATION AND DIFFERENTIATION;MUTAGENESIS OF TYR-653 AND TYR-654
26.

"Receptor specificity of the fibroblast growth factor family."
Ornitz D.M. , Xu J. , Colvin J.S. , McEwen D.G. , MacArthur C.A. , Coulier F. , Gao G. , Goldfarb M.
J. Biol. Chem.271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGF1; FGF2; FGF4; FGF5; FGF6;FUNCTION IN CELL PROLIFERATION
27.

"Structure of a heparin-linked biologically active dimer of fibroblast growth factor."
DiGabriele A.D. , Lax I. , Chen D.I. , Svahn C.M. , Jaye M. , Schlessinger J. , Hendrickson W.A.
Nature393:812-817(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGF1;PHOSPHORYLATION
28.

"The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1."
Popovici C. , Zhang B. , Gregoire M.-J. , Jonveaux P. , Lafage-Pochitaloff M. , Birnbaum D. , Pebusque M.-J.
Blood93:1381-1389(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH FGFR1OP
29.

"Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis."
Wang J. , Dai H. , Yousaf N. , Moussaif M. , Deng Y. , Boufelliga A. , Swamy O.R. , Leone M.E. , Riedel H.
Mol. Cell. Biol.19:6217-6228(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB10
30.

"FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)."
Guasch G. , Mack G.J. , Popovici C. , Dastugue N. , Birnbaum D. , Rattner J.B. , Pebusque M.-J.
Blood95:1788-1796(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH CNTRL
31.

"Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins."
Ong S.H. , Hadari Y.R. , Gotoh N. , Guy G.R. , Schlessinger J. , Lax I.
Proc. Natl. Acad. Sci. U.S.A.98:6074-6079(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF FRS2 AND GAB1 AND IN ACTIVATION OF PIK3R1
32.

"The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells."
Cross M.J. , Lu L. , Magnusson P. , Nyqvist D. , Holmqvist K. , Welsh M. , Claesson-Welsh L.
Mol. Biol. Cell13:2881-2893(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF SIGNALING VIA RAS AND MAP KINASES AND CELL PROLIFERATION;FUNCTION IN PHOSPHORYLATION OF FRS2; SHB AND PTPN11/SHP2;INTERACTION WITH SHB AND FGF2;MUTAGENESIS OF TYR-766
33.

"Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome."
Grand E.K. , Grand F.H. , Chase A.J. , Ross F.M. , Corcoran M.M. , Oscier D.G. , Cross N.C.P.
Genes Chromosomes Cancer40:78-83(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH FGFR1OP2
34.

"90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling."
Hu Y. , Fang X. , Dunham S.M. , Prada C. , Stachowiak E.K. , Stachowiak M.K.
J. Biol. Chem.279:29325-29335(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF RPS6KA1 AND CREB1;CATALYTIC ACTIVITY;INTERACTION WITH RPS6KA1;MUTAGENESIS OF LYS-514;SUBCELLULAR LOCATION
35.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-296
tissue: Plasma.
36.

"Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia."
Gu T.-L. , Goss V.L. , Reeves C. , Popova L. , Nardone J. , Macneill J. , Walters D.K. , Wang Y. , Rush J. , Comb M.J. , Druker B.J. , Polakiewicz R.D.
Blood108:4202-4204(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH FGFR1OP2
37.

"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
Zhang X. , Ibrahimi O.A. , Olsen S.K. , Umemori H. , Mohammadi M. , Ornitz D.M.
J. Biol. Chem.281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGF1; FGF8; FGF10; FGF19; FGF21; FGF22 AND FGF23;FUNCTION IN STIMULATION OF CELL PROLIFERATION
38.

"Factors controlling fibroblast growth factor receptor-1's cytoplasmic trafficking and its regulation as revealed by FRAP analysis."
Dunham-Ems S.M. , Pudavar H.E. , Myers J.M. , Maher P.A. , Prasad P.N. , Stachowiak M.K.
Mol. Biol. Cell17:2223-2235(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;GLYCOSYLATION
39.

"Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction."
Furdui C.M. , Lew E.D. , Schlessinger J. , Anderson K.S.
Mol. Cell21:711-717(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-463; TYR-653; TYR-654; TYR-583 AND TYR-585;IDENTIFICATION BY MASS SPECTROMETRY
40.

"14-3-3 integrates pro-survival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1 transformed hematopoietic cells."
Dong S. , Kang S. , Gu T. , Kardar S. , Fu H. , Lonial S. , Khoury H.J. , Khuri F. , Chen J.
Blood110:360-369(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH FGFR1OP2
41.

"Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21."
Kurosu H. , Choi M. , Ogawa Y. , Dickson A.S. , Goetz R. , Eliseenkova A.V. , Mohammadi M. , Rosenblatt K.P. , Kliewer S.A. , Kuro-o M.
J. Biol. Chem.282:26687-26695(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGF19; FGF21 AND KLB;FUNCTION IN REGULATION OF GLUCOSE UPTAKE IN ADIPOCYTES
42.

"Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the Golgi apparatus without translocation to the nucleus."
Citores L. , Bai L. , Sorensen V. , Olsnes S.
J. Cell. Physiol.212:148-156(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN STAT1 PHOSPHORYLATION;GLYCOSYLATION;PHOSPHORYLATION
43.

"Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis."
Haugsten E.M. , Malecki J. , Bjorklund S.M. , Olsnes S. , Wesche J.
Mol. Biol. Cell19:3390-3403(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;CATALYTIC ACTIVITY;FUNCTION AS FGF1 RECEPTOR AND IN ACTIVATION OF PLCG1; FRS2; MAPK1/ERK2 AND MAPK3/ERK1;ENZYME REGULATION;SUBCELLULAR LOCATION
44.

"Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1."
Hu Y. , Guimond S.E. , Travers P. , Cadman S. , Hohenester E. , Turnbull J.E. , Kim S.H. , Bouloux P.M.
J. Biol. Chem.284:29905-29920(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KAL1
45.

"Fibroblast growth factor receptor-1 (FGFR1) nuclear dynamics reveal a novel mechanism in transcription control."
Dunham-Ems S.M. , Lee Y.W. , Stachowiak E.K. , Pudavar H. , Claus P. , Prasad P.N. , Stachowiak M.K.
Mol. Biol. Cell20:2401-2412(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CHROMATIN BINDING AND TRANSCRIPTION REGULATION;SUBCELLULAR LOCATION
46.

"The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations."
Lew E.D. , Furdui C.M. , Anderson K.S. , Schlessinger J.
Sci. Signal.2:RA6-RA6(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PROTO-ONCOGENE;ACTIVE SITE;MUTAGENESIS OF ASN-546 AND ASP-623;CATALYTIC ACTIVITY;PHOSPHORYLATION AT TYR-463; TYR-653; TYR-654; TYR-583; TYR-585 AND TYR-730;IDENTIFICATION BY MASS SPECTROMETRY;ENZYME REGULATION
47.

"Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation."
Goetz R. , Nakada Y. , Hu M.C. , Kurosu H. , Wang L. , Nakatani T. , Shi M. , Eliseenkova A.V. , Razzaque M.S. , Moe O.W. , Kuro-o M. , Mohammadi M.
Proc. Natl. Acad. Sci. U.S.A.107:407-412(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGF23 AND KLB
48.

"Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function."
Persaud A. , Alberts P. , Hayes M. , Guettler S. , Clarke I. , Sicheri F. , Dirks P. , Ciruna B. , Rotin D.
EMBO J.30:3259-3273(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF AKT1; PLCG1; MAPK1/ERK2;MAPK3/ERK1 AND MAP KINASE SIGNALING;FUNCTION IN REGULATION OF NEURONAL DIFFERENTIATION AND EMBRYONIC DEVELOPMENT;SUBCELLULAR LOCATION;INTERACTION WITH NEDD4; PLCG1 AND FRS2;UBIQUITINATION;DEGRADATION
49.

"The structure and function of vertebrate fibroblast growth factor receptor 1."
Groth C. , Lardelli M.
Int. J. Dev. Biol.46:393-400(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ALTERNATIVE SPLICE FORMS; LIGANDS; SIGNALING PATHWAYS AND SUBCELLULAR LOCATION
50.

"Cellular signaling by fibroblast growth factor receptors."
Eswarakumar V.P. , Lax I. , Schlessinger J.
Cytokine Growth Factor Rev.16:139-149(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION; ROLE IN DISEASE; SIGNALING PATHWAYS; SUBUNIT; DOMAIN STRUCTURE; LIGAND SELECTIVITY AND ENZYME REGULATION
51.

"Fibroblast growth factor signalling: from development to cancer."
Turner N. , Grose R.
Nat. Rev. Cancer10:116-129(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN FGF SIGNALING
52.

"Novel insights in FGFR1 regulation: lessons from Kallmann syndrome."
Hu Y. , Bouloux P.M.
Trends Endocrinol. Metab.21:385-393(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON SIGNALING AND ROLE IN KALLMAN SYNDROME
53.

"Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism."
Mohammadi M. , Schlessinger J. , Hubbard S.R.
Cell86:577-587(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 464-762
54.

"Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors."
Mohammadi M. , McMahon G. , Sun L. , Tang C. , Hirth P. , Yeh B.K. , Hubbard S.R. , Schlessinger J.
Science276:955-960(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 464-762 IN COMPLEX WITH SU4984
55.

"Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity."
Plotnikov A.N. , Hubbard S.R. , Schlessinger J. , Mohammadi M.
Cell101:413-424(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 141-365 IN COMPLEX WITH FGF1;FUNCTION;DISULFIDE BONDS
56.

"Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization."
Schlessinger J. , Plotnikov A.N. , Ibrahimi O.A. , Eliseenkova A.V. , Yeh B.K. , Yayon A. , Linhardt R.J. , Mohammadi M.
Mol. Cell6:743-750(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 143-364 IN COMPLEX WITH FGF2 AND HEPARIN;DISULFIDE BONDS
57.

"Solution structure of the first Ig-like domain of human fibroblast growth factor receptor 1."
RIKEN structural genomics initiative (RSGI)
Submitted (2005-11) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 38-124
58.

"The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site."
Bae J.H. , Lew E.D. , Yuzawa S. , Tome F. , Lax I. , Schlessinger J.
Cell138:514-524(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 458-774 IN COMPLEX WITH PLCG1 AND ATP ANALOG;FUNCTION;CATALYTIC ACTIVITY;SUBUNIT;AUTOPHOSPHORYLATION;PHOSPHORYLATION AT TYR-653; TYR-654 AND TYR-766
59.

"Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells."
Bae J.H. , Boggon T.J. , Tome F. , Mandiyan V. , Lax I. , Schlessinger J.
Proc. Natl. Acad. Sci. U.S.A.107:2866-2871(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 458-765 OF MUTANT GLU-577;FUNCTION;CATALYTIC ACTIVITY;SUBUNIT;MUTAGENESIS OF ARG-577
60.

"A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor."
Eathiraj S. , Palma R. , Hirschi M. , Volckova E. , Nakuci E. , Castro J. , Chen C.R. , Chan T.C. , France D.S. , Ashwell M.A.
J. Biol. Chem.286:20677-20687(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 461-765 IN COMPLEX WITH ARQ 069;ENZYME REGULATION
61.

"A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome."
Muenke M. , Schell U. , Hehr A. , Robin N.H. , Losken H.W. , Schinzel A. , Pulleyn L.J. , Rutland P. , Reardon W. , Malcolm S. , Winter R.M.
Nat. Genet.8:269-274(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PS ARG-252
62.

"An unusual FGFR1 mutation (fibroblast growth factor receptor 1 mutation) in a girl with non-syndromic trigonocephaly."
Kress W. , Petersen B. , Collmann H. , Grimm T.
Cytogenet. Cell Genet.91:138-140(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRIGNO1 THR-300
63.

"Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome."
Dode C. , Levilliers J. , Dupont J.-M. , De Paepe A. , Le Du N. , Soussi-Yanicostas N. , Coimbra R.S. , Delmaghani S. , Compain-Nouaille S. , Baverel F. , Pecheux C. , Le Tessier D. , Cruaud C. , Delpech M. , Speleman F. , Vermeulen S. , Amalfitano A. , Bachelot Y. , more...
Nat. Genet.33:463-465(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH2 ASP-97; CYS-99; SER-167; TYR-277; MET-607; ARG-666; ARG-719 AND SER-772
64.

"Clinical assessment and mutation analysis of Kallmann syndrome 1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1, or KAL2) in five families and 18 sporadic patients."
Sato N. , Katsumata N. , Kagami M. , Hasegawa T. , Hori N. , Kawakita S. , Minowada S. , Shimotsuka A. , Shishiba Y. , Yokozawa M. , Yasuda T. , Nagasaki K. , Hasegawa D. , Hasegawa Y. , Tachibana K. , Naiki Y. , Horikawa R. , Tanaka T. , more...
J. Clin. Endocrinol. Metab.89:1079-1088(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HH2 SER-745
65.

"Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation."
White K.E. , Cabral J.M. , Davis S.I. , Fishburn T. , Evans W.E. , Ichikawa S. , Fields J. , Yu X. , Shaw N.J. , McLellan N.J. , McKeown C. , FitzPatrick D. , Yu K. , Ornitz D.M. , Econs M.J.
Am. J. Hum. Genet.76:361-367(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OGD ILE-330; CYS-374 AND ARG-381;CHARACTERIZATION OF VARIANT OGD CYS-374
66.

"Kallmann syndrome: 14 novel mutations in KAL1 and FGFR1 (KAL2)."
Albuisson J. , Pecheux C. , Carel J.-C. , Lacombe D. , Leheup B. , Lapuzina P. , Bouchard P. , Legius E. , Matthijs G. , Wasniewska M. , Delpech M. , Young J. , Hardelin J.-P. , Dode C.
Hum. Mutat.25:98-99(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH2 ILE-102; ALA-129; MET-273 AND THR-520
67.

"Gonadotrophin therapy in Kallmann syndrome caused by heterozygous mutations of the gene for fibroblast growth factor receptor 1: report of three families: case report."
Sato N. , Hasegawa T. , Hori N. , Fukami M. , Yoshimura Y. , Ogata T.
Hum. Reprod.20:2173-2178(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH2 ARG-687 AND SER-745
68.

"Extended mutational analyses of FGFR1 in osteoglophonic dysplasia."
Farrow E.G. , Davis S.I. , Mooney S.D. , Beighton P. , Mascarenhas L. , Gutierrez Y.R. , Pitukcheewanont P. , White K.E.
Am. J. Med. Genet. A140:537-539(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OGD ILE-330 AND ARG-381
69.

"Novel fibroblast growth factor receptor 1 mutations in patients with congenital hypogonadotropic hypogonadism with and without anosmia."
Trarbach E.B. , Costa E.M.F. , Versiani B. , de Castro M. , Baptista M.T.M. , Garmes H.M. , de Mendonca B.B. , Latronico A.C.
J. Clin. Endocrinol. Metab.91:4006-4012(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH2 SER-48; PRO-245; TRP-250; VAL-343; LEU-366; SER-722 AND ILE-795
70.

"Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes."
Pitteloud N. , Meysing A. , Quinton R. , Acierno J.S. Jr. , Dwyer A.A. , Plummer L. , Fliers E. , Boepple P. , Hayes F. , Seminara S. , Hughes V.A. , Ma J. , Bouloux P. , Mohammadi M. , Crowley W.F. Jr.
Mol. Cell. Endocrinol.254:60-69(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH2 CYS-78; ILE-102; HIS-224; ASP-237; GLN-254; MET-273; GLY-274 CYS-339; CYS-346; VAL-538; ARG-703 AND SER-703;VARIANT VAL-769
71.

"Paediatric phenotype of Kallmann syndrome due to mutations of fibroblast growth factor receptor 1 (FGFR1)."
Zenaty D. , Bretones P. , Lambe C. , Guemas I. , David M. , Leger J. , de Roux N.
Mol. Cell. Endocrinol.254:78-83(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH2 SER-178; GLY-622 AND GLN-622
72.

"Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism."
Pitteloud N. , Acierno J.S. Jr. , Meysing A. , Eliseenkova A.V. , Ma J. , Ibrahimi O.A. , Metzger D.L. , Hayes F.J. , Dwyer A.A. , Hughes V.A. , Yialamas M. , Hall J.E. , Grant E. , Mohammadi M. , Crowley W.F. Jr.
Proc. Natl. Acad. Sci. U.S.A.103:6281-6286(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH2 SER-237; HIS-722 AND LYS-724;CHARACTERIZATION OF VARIANTS HH2 SER-237; HIS-722 AND LYS-724
73.

"Novel FGFR1 sequence variants in Kallmann syndrome, and genetic evidence that the FGFR1c isoform is required in olfactory bulb and palate morphogenesis."
Dode C. , Fouveaut C. , Mortier G. , Janssens S. , Bertherat J. , Mahoudeau J. , Kottler M.-L. , Chabrolle C. , Gancel A. , Francois I. , Devriendt K. , Wolczynski S. , Pugeat M. , Pineiro-Garcia A. , Murat A. , Bouchard P. , Young J. , Delpech M. , more...
Hum. Mutat.28:97-98(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH2 PHE-101; TRP-250; ASP-270; ARG-283; CYS-332; ARG-621; PHE-685; PHE-693 AND SER-772;VARIANTS LYS-77 AND CYS-822
74.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-125; THR-252 AND LEU-664
75.

"Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism."
Raivio T. , Sidis Y. , Plummer L. , Chen H. , Ma J. , Mukherjee A. , Jacobson-Dickman E. , Quinton R. , Van Vliet G. , Lavoie H. , Hughes V.A. , Dwyer A. , Hayes F.J. , Xu S. , Sparks S. , Kaiser U.B. , Mohammadi M. , Pitteloud N.
J. Clin. Endocrinol. Metab.94:4380-4390(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH2 CYS-99; SER-117; ASP-228; THR-239; GLN-250; LEU-470; ASN-618 AND PRO-671;CHARACTERIZATION OF VARIANTS HH2 CYS-99; SER-117; ASP-228; THR-239; GLN-250; LEU-470; ASN-618 AND PRO-671
76.

"Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism."
Tornberg J. , Sykiotis G.P. , Keefe K. , Plummer L. , Hoang X. , Hall J.E. , Quinton R. , Seminara S.B. , Hughes V. , Van Vliet G. , Van Uum S. , Crowley W.F. , Habuchi H. , Kimata K. , Pitteloud N. , Bulow H.E.
Proc. Natl. Acad. Sci. U.S.A.108:11524-11529(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HH2 GLN-250
77.

"SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome."
Hanchate N.K. , Giacobini P. , Lhuillier P. , Parkash J. , Espy C. , Fouveaut C. , Leroy C. , Baron S. , Campagne C. , Vanacker C. , Collier F. , Cruaud C. , Meyer V. , Garcia-Pinero A. , Dewailly D. , Cortet-Rudelli C. , Gersak K. , Metz C. , more...
PLoS Genet.8:E1002896-E1002896(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HH2 ARG-687
78.

"Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism."
Miraoui H. , Dwyer A.A. , Sykiotis G.P. , Plummer L. , Chung W. , Feng B. , Beenken A. , Clarke J. , Pers T.H. , Dworzynski P. , Keefe K. , Niedziela M. , Raivio T. , Crowley W.F. Jr. , Seminara S.B. , Quinton R. , Hughes V.A. , Kumanov P. , more...
Am. J. Hum. Genet.92:725-743(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH2 SER-117; ASP-228; THR-239; GLN-250; SER-342; ARG-348; LEU-470; THR-483; ASN-618; LYS-670; GLY-692; HIS-722; LYS-724 AND TYR-768
79.

"FGFR1 mutations cause Hartsfield syndrome, the unique association of holoprosencephaly and ectrodactyly."
Simonis N. , Migeotte I. , Lambert N. , Perazzolo C. , de Silva D.C. , Dimitrov B. , Heinrichs C. , Janssens S. , Kerr B. , Mortier G. , Van Vliet G. , Lepage P. , Casimir G. , Abramowicz M. , Smits G. , Vilain C.
J. Med. Genet.50:585-592(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HRTFDS;VARIANTS HRTFDS SER-165; SER-191; ARG-490; TYR-623; LYS-628 AND TYR-725
80.

"Novel de novo heterozygous FGFR1 mutation in two siblings with Hartsfield syndrome: A case of gonadal mosaicism."
Dhamija R. , Kirmani S. , Wang X. , Ferber M.J. , Wieben E.D. , Lazaridis K.N. , Babovic-Vuksanovic D.
Am. J. Med. Genet. A164:2356-2359(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HRTFDS THR-627

Product Feedback Wall

* Email:
*Comments: